Collaboration is paramount to providing the best possible care to Mayo Clinic patients. In fact, the three shields of the Mayo Clinic logo represent Research, Education, and the Clinical Practice; these three fields converge to leverage the benefits of each and ensure that the needs of the patient come first. When talented professionals come together to determine the best possible way to proceed with patient care, the result is innovation. Since 2006, Mayo Clinic’s Department of Surgery, Department of Radiology, and Division of Engineering have collaborated to produce patient-specific anatomic models that help to educate patients, families, and care teams in surgical understanding and preparation. In the years to follow, this three-part link has allowed point-of-care surgical planning to transform from simple visual-aid models to full anatomical replicas with life-like tissue responses. Within the last four years, surgical planning has expanded into the production of patient-specific tools, guides, and fixtures to aid with carrying out a digital plan made pre-operatively by the surgical team. This didactic presentation will cover the advanced point-of-care surgical planning elements as they relate to medicine, engineering, and manufacturing.