Renishaw – First Clinical Study Patient Has Novel Drug Delivery System Implanted for Parkinson’s Trial


On November 8th, 2017 the first patient in a new clinical study was implanted with a novel drug delivery system, developed by Renishaw, The procedure took place at Karolinska University Hospital in Stockholm, Sweden. The implantation marks the beginning of a joint clinical study between Renishaw and Herantis Pharma. This phase I – II clinical study will investigate the treatment of Parkinson’s disease using Cerebral Dopamine Neurotrophic Factor (CDNF) delivered with Renishaw’s system.

Parkinson’s disease is a common debilitating neurodegenerative disease affecting seven million people worldwide. It causes tremors, muscle stiffness and slowness of movement and current therapies treat these symptoms alone. One challenge in developing treatments for this disease is the blood brain barrier, which prevents large molecules from accessing the brain tissue.

The first patient in a new clinical study was implanted with a novel drug delivery system, which was partly additively manufactured by global engineering company, Renishaw.  (Photo courtesy of Renishaw)

The first patient in a new clinical study was implanted with a novel drug delivery system, which was partly additively manufactured by global engineering company, Renishaw. (Photo courtesy of Renishaw)

“Renishaw’s drug delivery system could be revolutionary in improving treatment options for Parkinson’s disease,” explained Paul Skinner, General Manager for Renishaw’s Neurological Products Division. “The system enables the delivery of large drug molecules, such as CDNF, directly into the brain – circumventing the blood brain barrier.”

“The drug delivery system consists of four catheters which, during the procedure, are accurately implanted into the patient’s putamen, one of the key regions of the brain affected by Parkinson’s disease,” continued Skinner. “The catheters converge in a port mounted to the skull behind the ear, through which drugs will be administered on a monthly basis as part of the study. The system can also be used with other new drug candidates that need to be delivered to precise areas of the brain, which could be crucial in the development of treatments for this and other debilitating diseases.”

The study will involve 18 volunteers across three sites — two in Sweden and one in Finland. It will evaluate the safety and tolerability of the drug delivery system and CDNF, a large molecule that could slow the progression of Parkinson’s disease, improving the quality of life for patients and prolong their lives. For six months, each volunteer will receive monthly infusions of CDNF, or artificial CerebroSpinal Fluid (aCSF) for those receiving the placebo, via the drug delivery system.

The clinical study has received funding from Horizon 2020, the European Union’s research and innovation programme. Following this study, it is hoped that the drug delivery system will be used in clinical trials for the treatment of other neurological conditions, including brain tumours and Huntington’s disease.

For more information about Renishaw’s neurological product range, visit

About Renishaw
UK-based Renishaw is a world leading engineering technologies company, supplying products used for applications as diverse as jet engine and wind turbine manufacture, through to dentistry and brain surgery. It has over 4,000 employees located in the 35 countries where it has wholly owned subsidiary operations.

For the year ended June 2017 Renishaw recorded sales of £536.8 million of which 95% was due to exports. The company’s largest markets are China, the USA, Japan and Germany.

Throughout its history Renishaw has made a significant commitment to research and development, with historically between 14 and 18% of annual sales invested in R&D and engineering. The majority of this R&D and manufacturing of the company’s products is carried out in the UK.

The Company’s success has been recognised with numerous international awards, including eighteen Queen’s Awards recognising achievements in technology, export and innovation.

Further information at

Source: Renishaw


  1. Am a male aged 60 and diagnosed with Parkinson”s at 59. I had some symptoms for a few years before diagnosis; stiff achy right arm and ankle, right hand tremor when typing, tiredness, body shivers, falls due to tripping. I was always active, bicycle riding to/from work daily and putting in 2 to 3,000 miles on my bicycle per year. i was on Mysoline 250mg in 3 doses for the essential tremor. Madopar 200mgfour times a day. Sifrol 1mg three times a day, I started on Health Herbal Clinic Parkinsons Disease Herbal formula treatment in November 2016, i read alot of positive reviews on their success rate treating Parkinsons disease through their PD Herbal formula and i immediately started on the treatment. Just 8 weeks into the Herbal formula treatment I had great improvements, my hand tremors seized. I am unbelievably back on my feet again, visit Health Herbal Clinic official website www. healthherbalclinic. net or email info@ healthherbalclinic. net.My have reduced my symptoms have so much reduced that now I hardly notice them.

  2. I have been diagnosed with Parkinson’s disease even though I don’t have the DaTscan until may 22. I was being tested for multiple sclerosis and have been displaying symptoms for around 3 years, shaking, twitching, rigidity, neck pain and anxiety. I am a 61 year old female.
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